Evidence map›Paper›PMID 42571578›Full record

ReviewSchizophrenia bulletin open2026

The Lived Experience of Paranoia: Systematic Review of Qualitative Studies.

Angela Muscettola, Giulia Drusiani, Martina Desenzani, Ludovico Belluardo, Giovanni Antonio De Bellis, Lisa Bortolotti, Chiara Montemitro, Andrea Escelsior, Luigi Zerbinati, Tommaso Toffanin and 4 more

Abstract readReview
In one paragraph

Review in Schizophrenia bulletin open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Angela MuscettolaInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.ORCID https://orcid.org/0009-0008-8905-5142
Giulia DrusianiInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Martina DesenzaniInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Ludovico BelluardoInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Giovanni Antonio De BellisInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Lisa BortolottiInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Chiara MontemitroInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Andrea EscelsiorSection of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genova, Italy.
Luigi ZerbinatiInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Tommaso ToffaninInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Rosangela CarusoInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Maria Giulia NanniInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Luigi GrassiInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.
Martino Belvederi MurriInstitute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Hypothesis: Paranoia is commonly conceptualized along a continuum ranging from transient suspiciousness and mistrust to fixed persecutory delusions. However, similar paranoid contents may differ in conviction, flexibility, self-reference, distress, functional impact, and embeddedness in broader changes of self, agency, and world-experience. We synthesized qualitative evidence on the subjective experience of paranoia, suspiciousness, mistrust, and persecutory threat. Study Design: Following PRISMA and ENTREQ guidance, we searched PubMed/MEDLINE, Embase, PsycINFO, Scopus, EBSCOhost, and Ovid from inception to January 31, 2026. Thirty-six qualitative, experiential, or mixed-methods studies were included. Data were analyzed using thematic synthesis informed by phenomenological principles. Studies were classified as core evidence when paranoia was central, or contextual evidence when paranoia-related material was embedded within broader phenomena. Study Results: Three superordinate themes were generated: From interpersonal vigilance to a persecutory world; The threatened self: shame, vulnerability, trauma, and social injury; and Restoring meaning and safety: agency, coping, and altered reality. Paranoia emerged not only as a belief about threat, but as a situated transformation in the relation between self, others, and world. Lower-severity and non-clinical accounts were generally more localized, reflective, and negotiable. Clinical and higher-severity accounts were more pervasive, embodied, self-referential, and reality-defining, often intertwined with voices, external control, altered agency, spiritual meanings, or changes in reality-experience. Conclusions: Paranoia is a multidimensional lived experience shaped by interpersonal threat, self-vulnerability, trauma, sociocultural context, coping, and meaning-making. Assessment should consider what paranoid beliefs mean, what they do for the person, and how they are shaped by biography, context, and lived experience.

Indexed as

epistemic injusticehelp-seekingparanoiapersecutory delusionspsychosisqualitative synthesissubjective experience

Identifiers

PMID42571578
PMCPMC13452461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.