ArticleCureus2026
Central Nervous System Manifestations of Rosai-Dorfman Disease: A Case Series.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Rosai-Dorfman disease (RDD) with central nervous system (CNS) involvement poses substantial diagnostic challenges due to its propensity to mimic meningiomas or inflammatory pathologies. We present a series of three RDD cases with CNS involvement to evaluate their clinical, radiological, and histopathological features. The series includes a 30-year-old female with pachymeningitis and spinal involvement; a 66-year-old male with a skull base lesion; and a 45-year-old male presenting with trigeminal neuralgia secondary to a cavernous sinus lesion. In all instances, definitive diagnosis was achieved following surgical intervention and histopathological analysis, revealing hallmark emperipolesis and a characteristic immunohistochemical profile (S100+, CD68+, and CD1a-). Management comprised neurosurgical resection for decompression and diagnosis, supplemented by adjuvant corticosteroids and chemotherapy where indicated. This series underscores that RDD is a critical differential diagnosis for atypical extra-axial CNS lesions. A multidisciplinary approach is essential for optimizing patient outcomes.
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