ArticleClinical and translational radiation oncology2026
Characterization of skin microbiome profile before and during radiation therapy and its correlation to the occurrence and severity of radiation dermatitis.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose/objectives: The purpose of study is to characterize the skin microbiome profile of breast cancer patients before and during radiation therapy, and evaluate the relationship between the microbiome profile and the severity of acute radiation dermatitis (aRD). Materials/methods: In this observational, single-center, single-arm study, breast cancer patients received RT at Rambam Health Care Campus from November 2020 to July 2021. Skin assessments and skin microbiome samples were collected from all patients before, weekly during RT, after completion of the treatment. The outcome measures were: aRD grade, skin microbiome composition at baseline and during RT. Results: 640 skin samples were collected from 86 patients, bacterial DNA was extracted, and 16S rDNA was amplified and sequenced.At mid-treatment, the bacterial family Clostridiaceae was unique to patients later diagnosed with moderate/severe acute dermatitis, and present in 30% of the samples ( Conclusion: A bacterial composition associated with moderate/severe aRD was identified: Clostridium, Anaerococcus US436, and
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