Evidence map›Paper›PMID 42571388›Full record

ArticleNeurobiology of stress2026

Proenkephalin neurons in the adBNST mitigate stress-induced anxiety and estrous cycle disruption in female mice.

Wenwen Su, Yongxiu Song, Xia Zhang, Bin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wenwen SuSchool of Pharmacy, Qingdao Medical College of Qingdao University, Qingdao University, Qingdao, 266071, China.
Yongxiu SongSchool of Basic Medicine, Qingdao Medical College of Qingdao University, Qingdao University, Qingdao, 266071, China.
Xia ZhangSchool of Pharmacy, Qingdao Medical College of Qingdao University, Qingdao University, Qingdao, 266071, China.
Bin ZhangSchool of Basic Medicine, Qingdao Medical College of Qingdao University, Qingdao University, Qingdao, 266071, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic stress is a major risk factor for anxiety disorders and is often accompanied by disruptions in female reproductive cyclicity, but the stress-responsive neural populations that shape these comorbid behavioral and physiological outcomes remain poorly defined. The bed nucleus of the stria terminalis (BNST) is a major node for sustained anxiety and stress integration, yet the contribution of genetically defined BNST neurons to restraint stress is not fully resolved in females. Here, we identify proenkephalin-expressing neurons in the anterior dorsal BNST (adBNST

Indexed as

AnxietyBed nucleus of the stria terminalisChronic restraint stressEstrous cycleProenkephalin

Identifiers

PMID42571388
PMCPMC13452231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.