ArticleMetabolism open2026
Metabolic signature across Life's Essential 8 profiles is heterogenous and may predict cardiovascular disease and mortality.
Article in Metabolism open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
Background: Life's Essential 8 (LE8) is an American Heart Association framework of modifiable behaviors and factors for measuring cardiovascular health. However, the underlying metabolic signature of individual LE8 metrics is less known. The purpose of this study is to identify the metabolites associated with all 8 components of LE8 and evaluate association with adverse cardiovascular events. Methods: Modified baseline LE8 metrics were collected and metabolomic profiling (Metabolon, Inc) was completed in the Heart SCORE study participants. For each LE8 component pathway enrichment was assessed using Fisher's exact test across metabolite subpathways. A metabolic age ( Findings: Amongst 1,218 participants (mean age 59.1 ± 5.1 years; 67.1% women and 39.2% self-identified as Black), distinct metabolite patterns linked to different modified LE8 components were identified. Notably, favorable exercise scores had significant associations with plasmalogen metabolites. Optimal sleep health was most strongly associated with lower activity of the phosphatidylethanolamine pathway. In adults aged 65 years and older, higher accelerated Interpretation: All modified LE8 components show distinct metabolic patterns underscoring the biological heterogeneity of cardiovascular health behaviors. Notably,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.