ArticleCureus2026
Guillain-Barré Syndrome Following Orthopedic Trauma and Surgical Fixation: A Case of Acute Inflammatory Demyelinating Polyradiculoneuropathy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guillain-Barré syndrome (GBS) is an acute inflammatory immune-mediated polyradiculoneuropathy characterized by rapidly progressive ascending weakness, generalized areflexia, and varying degrees of cranial nerve involvement. Although antecedent respiratory and gastrointestinal infections are the most commonly seen triggers, an association between surgery and GBS has increasingly been recorded in recent years. Recognition in postoperative patients may be delayed because neurological deficits are commonly attributed to postoperative complications, prolonged immobility, metabolic abnormalities, or medication-related adverse effects. Although GBS following orthopedic surgery has been increasingly reported in recent years, it remains an important diagnostic challenge because postoperative neurological deficits are frequently attributed to surgical, metabolic, or medication-related causes, resulting in delayed diagnosis and treatment. We report the case of a 19-year-old male who developed rapidly progressive ascending quadriparesis with areflexia and right lower motor neuron facial palsy around 10 days after open reduction and internal fixation for left tibia and fibula fractures. Nerve conduction studies demonstrated demyelinating sensorimotor polyradiculoneuropathy consistent with the acute inflammatory demyelinating polyradiculoneuropathy type of GBS. Cerebrospinal fluid analysis showed albuminocytological dissociation. The patient was treated with intravenous immunoglobulin therapy and demonstrated remarkable neurological recovery with near-complete restoration of motor function at follow-up. This case highlights the diagnostic challenges associated with postoperative GBS and emphasizes the importance of maintaining a high index of suspicion in patients presenting with rapidly progressive weakness after orthopedic procedures. Early electrophysiological evaluation and prompt immunotherapy can result in excellent neurological recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.