ArticleDermatology research and practice2026
Effect of Transcutol P on Percutaneous Absorption of Gel Containing Pure Synthetic Caffeine or Plant-Extracted Natural Caffeine.
Article in Dermatology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of Transcutol P on Percutaneous Absorption of Gel Containing Pure Synthetic Caffeine or Plant-Extracted Natural Caffeine.Dermatology research and practice · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Caffeine, a safe methylxanthine, has been widely used for the treatment of skin diseases such as cellulite, hair loss, aging, and psoriasis. However, its skin penetration is low. Transcutol is a biocompatible, nonvolatile permeation enhancer which solubilize large number of drugs and does not change the integrity of the skin structure. Materials and methods: In this study, the skin permeability of synthetic and natural caffeine gels was compared by ex vivo experiments. Furthermore, Transcutol P was used as a permeation enhancer, and its impact on skin permeation enhancement was determined. Results: The skin penetration of caffeine from the formulation containing coffee extract, a type of natural caffeine, is higher than that of the formulation containing pure synthetic caffeine. This effect is likely due to the presence of coffee, which can act as a skin permeation enhancer. Additionally, the use of Transcutol P in a formulation containing coffee extract at a concentration of 2.5% caused the highest amount of flux. Therefore, the formulation of gel containing natural caffeine along with 2.5% Transcutol is optimal and can be used for further studies. Conclusion: It can be concluded that the addition of 2.5% Transcutol P in the formulation containing coffee extract resulted in the highest skin permeation.
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