ArticleInternational journal of fertility & sterility2026
Intracytoplasmic Sperm Injection Clinical Outcomes: A Non-Inferiority Comparison of The Novel Felix™ Electrophoretic System and Conventional Density Gradient Centrifugation for Sperm Selection, A Prospective Clinical Trial.
Article in International journal of fertility & sterility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: In intracytoplasmic sperm injection (ICSI), sperm selection has traditionally relied on motility and morphology, often overlooking DNA integrity. This study evaluates the Felix™ Electrophoretic System, which isolates sperm based on membrane surface electric charge, by assessing its effectiveness in selecting motile sperm with intact DNA and comparing ICSI clinical outcomes between the Felix™ system and density gradient centrifugation (DGC) in sibling oocytes. Materials and Methods: In this prospective clinical trial study, semen samples from 25 infertile couples were processed using both DGC and the Felix™ sperm preparation system. For ICSI, oocytes were fertilized with sperm prepared by each method. Embryo development was monitored using time-lapse imaging, and embryo quality was assessed on day 5 post-ICSI. The highest-quality embryo from each group was selected for transfer. Results: Fertilization rates and blastocyst quality were comparable between the two groups. Although the Felix ™ group exhibited a higher proportion of high-quality blastocysts than the DGC group, this difference was not statistically significant (P=0.220). The number of embryo transfers per couple varied depending on the availability of transferable embryos. In total, 16 embryo transfers were performed in the Felix™ group, resulting in a 37% clinical pregnancy rate, whereas 11 transfers were performed in the DGC group, resulting in a 36% clinical pregnancy rate. Conclusion: This pilot study demonstrated that the Felix™ system provides assisted reproductive technology (ART) outcomes comparable to those of DGC, while requiring less semen and time and avoiding centrifugal stress. However, larger studies and additional functional and long-term evaluations are needed to confirm its efficacy, safety, and impact on offspring health (registration number: IRCT20110804007223N11).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.