ArticleAnnals of Saudi medicine
Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUnexplained infertility remains a diagnostic and therapeutic challenge. Dual trigger, combining gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (hCG), has been proposed to more closely mimic the physiological mid-cycle gonadotropin surge than hCG alone in gonadotropin-stimulated intrauterine insemination (IUI) cycles.
objectivesTo evaluate whether dual trigger improves biochemical pregnancy outcomes compared with hCG-only trigger in gonadotropin-stimulated IUI cycles.
designRetrospective cohort study. SETTINGS: Single-center, tertiary referral center. PATIENTS AND
methodsBetween April 2021 and September 2022, 96 patients underwent IUI after ovarian stimulation with gonadotropins (53 hCG-only, 43 dual trigger). Baseline demographic and clinical characteristics included female age (29.5±2.5 vs. 27.2±3.5 years), male age (33.3±4.0 vs. 31.6±3.5 years), body mass index (BMI) (24.0 vs. 25.0 kg/m
main outcome measuresBiochemical pregnancy, defined as serum β-hCG ≥5 mIU/mL. SAMPLE SIZE: 96 patients (53 hCG-only, 43 dual trigger).
resultsBiochemical pregnancy occurred in 18.6% of the dual trigger group and 11.3% of the hCG-only group (
conclusionsDual trigger did not significantly improve biochemical pregnancy rates compared with hCG-only trigger (OR=1.8, 95% CI: 0.6-5.6). Infertility duration was the only significant predictor of treatment success. Larger multi-center trials are required due to the current study's limited power. LIMITATIONS: Retrospective design, single-center setting, and limited sample size may restrict generalizability.
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