ArticleNature communications2026
Healthy vaccinee effect in the evaluation of updated COVID-19 vaccines in elderly populations.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Established determinants of health in the elderly help guide routines for indicated vaccine administration, while unmeasured frailty may limit vaccine access. We evaluate the performance of the 2024-2025 COVID-19 vaccine adapted to the Omicron JN.1 lineage in a Swedish population aged ≥65 years (N = 245 696). Vaccine effectiveness (VE) on COVID-19-related hospitalization and a negative control outcome (NCO; all-cause mortality) are assessed in various cohorts between October 1, 2024 to March 31, 2025. The VE was 75% (95% CI 70%-79%) overall, and 84% (95% CI 80%-87%) and 65% (95% CI 34%-82%) in individuals with and without vaccination with the prior updated COVID-19 vaccine in 2023-2024, respectively. The NCO in individuals exposed to the study vaccine in 2024-2025 was half of that seen in those not exposed to the vaccine (HR 0.43 [95% CI 0.40-0.45]). Removing individuals hospitalized with COVID-19 from this population did not change the difference in NCO (HR 0.43 [95% CI 0.41-0.46]). These findings suggest the presence of selection effects arising from under-provision of health services to elderly individuals with frailty. The healthy vaccinee effect should be considered in observational studies of the effectiveness of updated COVID-19 vaccines in elderly populations.
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Registered trials
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