Evidence map›Paper›PMID 42570137›Full record

ReviewCurrent neurology and neuroscience reports2026

Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.

Rujuan Liu, Huali Gu, Xingyu Kang, Wei Chen, Chengfei Gao, Xiao Han, Lijun Meng, Ting Zhu, Zhengyu Gao

Abstract readReview
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In one paragraph

Review in Current neurology and neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rujuan Liu *Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Huali Gu *Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Xingyu KangDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Wei ChenDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Chengfei GaoDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Xiao HanDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Lijun MengDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Ting ZhuInstitute of Neuroregeneration and Neurorehabilitation, Bio-nano Pharmaceutical Joint Laboratory, Shandong Key Laboratory of Pathogenesis and Prevention of Brain Diseases, Qingdao Medical College, Qingdao University, Qingdao, 266071, China. zhuting0402@126.com.
Zhengyu GaoDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China. drgaozy@qdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThis review synthesizes the mechanisms, applications, and evidence gaps regarding pulsed radiofrequency (PRF) in the rehabilitation of post-stroke complications to guide its standardized integration. RECENT

findingsPRF, a minimally invasive neuromodulation technique, modulates neuronal excitability without thermal damage. Emerging evidence highlights multi-target effects, including improved microcirculation, suppressed neuroinflammation, and regulated neurotrophic factors. Clinically, PRF effectively alleviates refractory post-stroke pain and may indirectly ameliorate post-stroke depression while facilitating motor recovery. Image-guided procedures targeting specific nerves demonstrate favorable safety profiles. Despite promising outcomes for stroke rehabilitation, current evidence relies primarily on small case series and preclinical studies. Significant gaps remain in standardized protocols and high-quality randomized controlled trials. Further validation of long-term efficacy and safety is essential to establish PRF's definitive role in comprehensive post-stroke management.

Indexed as

Pulsed Radiofrequency TreatmentRecovery of FunctionStrokeStroke RehabilitationAnimalsHumansNeuroinflammationNeuroplasticityPost-stroke complicationsPulsed radiofrequencyStroke

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.