Evidence map›Paper›PMID 42570048›Full record

ArticleVeterinary research communications2026

Disseminated paracoccidioidomycosis in a black lion tamarin (Leontopithecus chrysopygus) confirmed by histopathology, molecular diagnostics and phylogenetic analysis of DNA from FFPE tissues.

Isabelle Dias de Oliveira, Isabella Galesi Tallach, Jamile Macedo Garcia, Gabrielle Fernanda Pereira da Silva Gagliotti, Jessica de Brito Ferreira Nascimento, Camila Santos da Silva Ferreira, Silvana Mello Pereira da Silva, Clarice Ribeiro Roque de Assumpção, Juliana Possatto Fernandes Takahashi, Julia de Carvalho and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Isabelle Dias de OliveiraPrograma de Pós Graduação em Ciências da Saúde do Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE, São Paulo, Brazil. isabelleoliveirad@gmail.com.
Isabella Galesi TallachCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Jamile Macedo GarciaCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Gabrielle Fernanda Pereira da Silva GagliottiCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Jessica de Brito Ferreira NascimentoCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Camila Santos da Silva FerreiraPrograma de Pós Graduação em Ciências da Saúde do Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE, São Paulo, Brazil.
Silvana Mello Pereira da SilvaCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Clarice Ribeiro Roque de AssumpçãoCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Juliana Possatto Fernandes TakahashiPrograma de Pós Graduação em Ciências da Saúde do Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE, São Paulo, Brazil.
Julia de CarvalhoCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Mayara Grego CaiaffaDepartamento de Conservação de Fauna Silvestre - Secretaria de Meio Ambiente, Infraestrutura e Logística do Estado de São Paulo, São Paulo, Brazil.
Daniela Etlinger-ColonelliCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Natália Coelho Couto de Azevedo FernandesCentro de Patologia, Instituto Adolfo Lutz, São Paulo, Brazil.
Leonardo José Tadeu de AraújoPrograma de Pós Graduação em Ciências da Saúde do Instituto de Assistência Médica ao Servidor Público Estadual - IAMSPE, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParacoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America, primarily affecting humans. Reports in non-human primates are rare and provide valuable insight into the environmental circulation of Paracoccidioides spp. and the interface between animal and human infection.  CASE REPORT: We describe a case of disseminated PCM in a 13-year-old black lion tamarin (Leontopithecus chrysopygus) from São Paulo, Brazil. The animal presented neurological signs and marked clinical deterioration, progressing to death within 48 h of the onset of neurological signs. Histopathological analysis of multiple organs revealed granulomatous inflammation associated with multiple budding yeast-like organisms consistent with Paracoccidioides spp., confirmed by Grocott staining. Molecular analysis of formalin-fixed, paraffin-embedded (FFPE) tissue by polymerase chain reaction (PCR) detected Paracoccidioides spp., and the resulting Sanger sequences clustered with reference sequences of the Paracoccidioides brasiliensis complex in the ITS-based phylogenetic analysis.

conclusionThis case demonstrates severe disseminated PCM in an endangered Neotropical primate and highlights the diagnostic value of combining histopathology and molecular assays in FFPE samples for etiological confirmation of fungal infections.

Indexed as

LeontopithecusMonkey DiseasesParacoccidioidesParacoccidioidomycosisAnimalsBrazilDNA, FungalFatal OutcomeMaleParaffin EmbeddingPhylogenyPolymerase Chain ReactionDNA, FungalLeontopithecusMolecular EpidemiologyOne HealthParacoccidioidomycosisPrimates

Identifiers

PMID42570048
PMCPMC13452848

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.