Evidence map›Paper›PMID 42570027›Full record

ArticleCellular and molecular life sciences : CMLS2026

Functional differences of Munc18 isoforms reflect their affinities for the exocytosis site.

Liangwen Liu, Santiago Echeverry, Muhmmad Omar-Hmeadi, Irina Česnokova, Per-Eric Lund, Jan Saras, Sebastian Barg

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liangwen LiuDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2918-8142
Santiago EcheverryDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Muhmmad Omar-HmeadiDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Irina ČesnokovaDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Per-Eric LundDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Jan SarasDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Sebastian BargDepartment of Medical Cell Biology, Uppsala University, Uppsala, Sweden. sebastian.barg@mcb.uu.se.ORCID http://orcid.org/0000-0003-4661-5724

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SM-protein Munc18 and its binding partner syntaxin are crucial for two distinct steps of regulated exocytosis, docking of secretory granules at the release site, and priming reactions that prepare docked granules for Ca

Indexed as

ExocytosisMunc18 ProteinsAnimalsInsulin-Secreting CellsMiceProtein BindingProtein IsoformsQa-SNARE ProteinsRatsSecretory VesiclesSyntaxin 1Munc18 ProteinsProtein IsoformsQa-SNARE ProteinsStxbp1 protein, ratSyntaxin 1DockingExocytosisInsulin granuleMunc18PrimingSyntaxin

Identifiers

PMID42570027
PMCPMC13452794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.