ArticleJournal of oral and maxillofacial pathology : JOMFP
Evaluation of c-Myc in odontogenic cysts and tumours-An immunohistochemical study.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To assess immunohistochemically the presence of c-Myc both qualitatively and quantitatively in odontogenic cysts and tumours and to correlate the results with biological behaviour of these lesions. Materials and Methods: Formalin-fixed, paraffin-embedded blocks of odontogenic cysts and tumours were retrieved from institutional archives. The study sample size was 45 ( Results: In the current study, the mean number of c-Myc positive cells in the odontogenic tumours was highest in solid Ameloblastoma (78.6 ± 11.59), followed by Adenomatoid odontogenic tumor (AOT) (75.30 ± 39.853) and least in unicystic ameloblastoma (56.6 ± 20.53). Among odontogenic cysts, the mean number of c-Myc positive cells was higher in Odontogenic keratocyst (OKC) (73.2 ± 17.937) compared to dentigerous cyst (28.0 ± 27.9) and radicular cysts (31.0 ± 31.7). The staining intensity varied in odontogenic cysts and tumours. Conclusion: The results and observations of the present study show that c-Myc plays a role in the aggressive biological behaviour of odontogenic lesions like ameloblastoma and OKC. So, it can be used as a proliferative marker. However, additional immunohistochemical and DNA assays are to be carried to determine the role of c-Myc oncogene and to know if any mutations may play a role in the pathogenesis of these odontogenic lesions.
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