ArticleJournal of oral and maxillofacial pathology : JOMFP
Evaluation of lymph node micrometastasis in oral squamous cell carcinoma - A retrospective histopathological study.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Context: Cervical lymph node metastasis is the most important prognostic factor in squamous cell carcinoma of head and neck. Lymph node prognostic determinants hold immense significance in influencing both patient's survival outcomes and the propensity for recurrence. Aims: To evaluate the diagnostic accuracy of Cyclin D1 and Pan-Cytokeratin (Pan-CK) for the detection of lymph node micrometastasis in oral squamous cell carcinoma (OSCC) tissue sections and re-assess the tumor staging. Settings and Design: Study was executed at Department of Oral and Maxillofacial Pathology and Oral Microbiology, Faculty of Dental Sciences, M.S. Ramaiah University of Applied Sciences, Karnataka, Bangalore, India and study design was Materials and Methods: A total of 30 N Results: Pan-CK and Cyclin D1 was helpful in detecting micrometastasis in 16.66% of N Conclusions: Pan-CK and Cyclin D1 were specific in detecting micrometastatic deposits compared H&E and PAP stains. Cyclin D1 immunostaining detects molecular overexpression in tumor cells missed on PAP or H&E, enabling identification of small lymph node deposits and improving staging accuracy and patient management.
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