ReviewEnvironmental epigenetics2026
Silent regulators of trauma: the microRNA blueprint underlying post-traumatic stress disorder biology.
Review in Environmental epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) is a chronic and disabling psychiatric condition that affects millions of people worldwide, producing persistent disturbances in emotional regulation, cognition, and physiological functioning. Although exposure to traumatic or life-threatening events is a defining feature of PTSD, only a subset of exposed individuals develop enduring symptoms, highlighting variability in vulnerability and recovery. The biological mechanisms underlying PTSD remain incompletely understood. Increasing evidence suggests that epigenetic processes play a central role in shaping individual responses to trauma. Among these, microRNAs (miRNAs), small, noncoding RNA molecules that fine-tune gene expression by regulating the translation and stability of multiple target genes simultaneously, have emerged as important epigenetic regulators of PTSD-related neurobiology. Because a single miRNA can influence extensive gene networks, alterations in miRNA expression affect a broad range of biological processes relevant to PTSD, including hypothalamic-pituitary-adrenal (HPA) axis function, synaptic plasticity, immune signaling, and memory formation. Recent studies demonstrate that dysregulated miRNAs can modify glucocorticoid receptor sensitivity, shape fear memory acquisition and extinction, and contribute to the proinflammatory phenotype frequently observed in PTSD. Progress of miRNA research in this field has been driven by integrative strategies that combine human peripheral tissues, plasma, and extracellular vesicles, complemented by animal models of stress and fear learning, including fear conditioning, restraint stress, and single-prolonged stress paradigms. Together, these approaches provide converging evidence for a critical role of miRNAs in PTSD pathophysiology. This review synthesizes findings across species to clarify miRNA-mediated mechanisms and highlight future directions for biomarker discovery and therapeutic development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.