ArticleJournal of oral and maxillofacial pathology : JOMFP
Evaluation of the immunohistochemical expression of DNA damage marker 8-OHdG in different histopathological grades of oral epithelial dysplasia.
Article in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The present investigation assessed the advanced oxidative stress end product, 8-hydroxydeoxyguanosine (8-OHdG), in oral epithelial dysplasia using immunohistochemistry (IHC) on tissue samples. Materials and methods: The study used tissue blocks from 40 patients with epithelial dysplasia. The diagnosis was confirmed by reviewing the hematoxylin-eosin slides. Normal mucosa tissue samples (n = 10) formed the control group. The intensity of immunohistochemical reactions was evaluated using light microscopy. The collected data were analyzed statistically using SPSS 26.0 to determine differences between the sample groups at a 5% significance level using Fisher's exact test. Results: Of the 40 leukoplakia with dysplasia samples examined, 5% showed high staining for 8-OHdG antigen, 25% had moderate staining, 37.5% had mild staining, and 43.33% showed no staining. Increased 8-OHdG antigen expression was found in dysplastic tissue samples ( Conclusion: The current investigation suggests that detecting 8-OHdG in potentially malignant oral disorders may be a reliable diagnostic indicator of oxidative DNA degeneration.
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