Evidence map›Paper›PMID 42569650›Full record

ArticleBrain communications2026

Hippocampal tissue mechanics are sensitive to fluctuations in oestrogen across the rat oestrous cycle.

Katrina A Milbocker, L Tyler Williams, Sabrina S Vander Wiele, Emma D Zarate, Hillary Schwarb, Elijah E W Van Houten, Elise A Corbin, Anna Y Klintsova, Curtis L Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katrina A MilbockerDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
L Tyler WilliamsDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Sabrina S Vander WieleDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Emma D ZarateDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Hillary SchwarbDepartment of Psychology, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Elijah E W Van HoutenUniversité de Strasbourg, CNRS, INSERM, ICube, UMR7357, Strasbourg, France.
Elise A CorbinDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.
Anna Y KlintsovaDepartment of Psychological & Brain Sciences, University of Delaware, Newark, DE 19716, USA.ORCID https://orcid.org/0000-0003-0626-8385
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA.ORCID https://orcid.org/0000-0002-7760-131X

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Gregory E Hicks · 2013 to 2026
$60.5M
Updated confocal microscope in the Imaging Core facility to support biomedical researchP20GM103653 · NIGMS · DELAWARE STATE UNIVERSITY · PI HARRINGTON, MELISSA A · 2012 to 2022
$22.7M
High-Resolution, Anisotropic MR Elastography of the BrainR01EB027577 · NIBIB · UNIVERSITY OF DELAWARE · PI BAYLY, PHILIP V, JOHNSON, CURTIS L · 2019 to 2022
$2.7M
Hippocampal-thalamo-prefrontal circuitry damage and therapeutic intervention in a model of FASDR01AA027269 · NIAAA · UNIVERSITY OF DELAWARE · PI KLINTSOVA, ANNA Y · 2019 to 2023
$2.0M
Changes in hippocampal microstructure and hippocampal-dependent memory accompanying hormonal fluctuation in naturally cycling womenR21MH127503 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHWARB, HILLARY · 2022 to 2023
$436k
NIAAA NIH HHS R01 AA027269NIBIB NIH HHS R01 EB027577NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM103653NIGMS NIH HHS U54 GM104941NIMH NIH HHS R21 MH127503
6 · The paper itself

Abstract

Sex hormones exert profound effects on brain structure and function throughout the female reproductive lifespan. While previous studies have documented hormone-dependent changes in neuronal morphology and synaptic connectivity, the impact of oestrogen on brain tissue mechanical properties has been unexplored. Alterations to hippocampal microstructure are particularly sensitive to fluctuations in sex steroids, and studies in peripheral tissues reveal that oestrogen is a powerful modulator of tissue elasticity and organization. Here, we employed magnetic resonance elastography (MRE) to quantify whole-brain and hippocampal viscoelastic properties across the oestrous cycle in female rats

Indexed as

biomarker development; oestrogenmagnetic resonance elastographyneuroimagingwomen’s brain health

Identifiers

PMID42569650
PMCPMC13450688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.