Trial reportDrug design, development and therapy2026
Postoperative Delirium After Dexmedetomidine versus Propofol Sedation in Older Adults Undergoing Hip Fracture Surgery with Spinal Anesthesia: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03346226 (Influence on Incidence of Postoperative Delirium by Various Sedatives in Elderly Patients With Hip Fracture Under Lumbar Anesthesia), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence on Incidence of Postoperative Delirium by Various Sedatives in Elderly Patients With Hip Fracture Under Lumbar Anesthesia: A Randomized, Control and Multi-center Trial
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Postoperative delirium is a prevalent complication in elderly surgical patients and is associated with adverse outcomes, including prolonged hospitalization and long-term cognitive impairment. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, has pharmacological properties that suggest it may reduce the incidence of postoperative delirium. This randomized controlled trial aimed to compare the incidence of postoperative delirium in elderly patients undergoing hip fracture repair under spinal anesthesia with propofol versus dexmedetomidine sedation. Patients and Methods: This multicenter, randomized, double-blind, parallel-group trial enrolled patients from 12 centers between September 2017 and July 2020. A total of 834 patients scheduled for hip fracture surgery were randomly assigned to receive either dexmedetomidine or propofol for intraoperative sedation. The primary outcome was the incidence of postoperative delirium within 72 hours postoperatively. Secondary outcomes included postoperative pain scores and other complications. Results: The incidence of postoperative delirium was significantly lower in the dexmedetomidine group compared to the propofol group (4.0% vs 7.8%; Conclusion: Dexmedetomidine sedation reduces the incidence of postoperative delirium in elderly patients undergoing hip fracture surgery under spinal anesthesia combined with iliac fascia block, compared to propofol sedation. Trial Registration: ClinicalTrials.gov, NCT03346226. Principal investigator: Zhanggang Xue. Registered on 14 September 2017.
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