Evidence map›Paper›PMID 42569618›Full record

ArticleCase reports in oncology

Complete Response to Pembrolizumab in Radiation-Induced Undifferentiated Pleomorphic Sarcoma of the Face: A Case Report and Review of the Literature.

Ethan Roman Leoni, Victor Lin, Caroline Bonaventure, Sagar Kansara

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ethan Roman LeoniDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Victor LinMary Bird Perkins Cancer Center, Baton Rouge, LA, USA.
Caroline BonaventureDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Sagar KansaraDepartment of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Undifferentiated pleomorphic sarcoma (UPS) as a secondary malignancy following adjuvant radiation therapy is rare and typically associated with poor prognosis. PD-1 inhibition has been previously investigated as a possible treatment in this space. Case Presentation: This case presents a 91-year-old male with UPS of the right parotid region, presumed secondary to radiation therapy for cutaneous squamous cell carcinoma. The patient was treated with pembrolizumab immunotherapy and a complete clinical response was achieved, with significant improvement noted on restaging scans. Treatment was well-tolerated despite advanced age and multiple comorbidities. Conclusion: This case demonstrates the efficacy of PD-1 inhibitor therapy in radiation-induced UPS and supports emerging evidence for immunotherapy as a viable treatment option in advanced or unresectable sarcomas, particularly with patients who cannot undergo surgery.

Indexed as

Cancer immunotherapy case reportPD-1 inhibitorUndifferentiated pleomorphic sarcoma

Identifiers

PMID42569618
PMCPMC13450989

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.