ArticlePeerJ2026
Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Sarcomatoid transformation in clear cell renal cell carcinoma (ccRCC) is associated with highly aggressive clinical behaviour and poor prognosis. The molecular basis underlying this transformation remains poorly defined. Methods: Formalin-fixed paraffin-embedded tumour samples from four patients with sarcomatoid ccRCC were analysed. Matched sarcomatoid, clear cell, and adjacent normal kidney tissues were subjected to gene expression profiling using the NanoString nCounter PanCancer Pathways Panel. Differential gene expression and pathway enrichment analyses were performed. External validation was conducted using The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC) dataset, and Gene Set Enrichment Analysis (GSEA) was used to assess pathway-level alterations. Results: Unsupervised clustering demonstrated clear segregation of sarcomatoid, clear cell, and normal kidney tissues. In the clear cell component, Conclusions: Sarcomatoid transformation in ccRCC is characterised by coordinated activation of epithelial-mesenchymal transition and invasive signalling pathways.
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