Evidence map›Paper›PMID 42569428›Full record

ArticleChemCatChem2025

Highly Enantioselective Synthesis of Halogenated Cyclopropanes via Enzyme Catalyzed Carbene Transfer.

Ronald Daisuke Adukure, Muhammed Fastheem, Vince Lombardo, Ryan Daley, Matthew Robinson, Tay Rosenthal, Rudi Fasan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemCatChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. JACS Au · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ronald Daisuke AdukureDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA.
Muhammed FastheemDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA.
Vince LombardoCrop Health R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Ryan DaleyCrop Health R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Matthew RobinsonCrop Health R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Tay RosenthalCrop Health R&D, Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Rudi FasanDepartment of Chemistry and Biochemistry, University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA.

Funding

Research Training in Complementary and Integrative MedicineT32AT000051 · NCCIH · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI GLORIA Y YEH · 1999 to 2026
$10.2M
Selective P450 Oxidation Catalysts for Synthesis of Bioactive MoleculesR01GM098628 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI FASAN, RUDI · 2012 to 2024
$4.7M
GINSENG'S EFFECTS ON MRNA PROFILES IN A DIABETES-2 MODELF32AT000051 · NCCIH · UNIVERSITY OF TEXAS AUSTIN · PI PAN, SHUJIA J · 1999 to 2001
$96k
NCCIH NIH HHS F32 AT000051NCCIH NIH HHS T32 AT000051NIGMS NIH HHS R01 GM098628
6 · The paper itself

Abstract

Halogenated cyclopropanes are highly desirable building blocks for both agrochemical and medicinal chemistry due to their unique structural features and ability to interact with biological targets through halogen bonds. However, methods for the highly diastreo- and enantioselective synthesis of these molecules are underdeveloped. Herein, we report the development of a new biocatalytic strategy to efficiently synthesize enantioenriched halogenated cyclopropanes through the enzymatic cyclopropanation of chloro- and bromo-substituted olefins in the presence of diazoacetonitrile using engineered myoglobin-based catalysts. This method tolerates a wide range of chloro- and bromo-containing olefins at both

Indexed as

BiocatalysisCarbene transferDiazoacetonitrileHalogenated cyclopropanesHemoproteinsMyoglobinProtein engineeringStereoselective Cyclopropanation

Identifiers

PMID42569428
PMCPMC13449911

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.