ArticleJournal of oral biology and craniofacial research
Effect of sequential Injectable Platelet Rich Fibrin (i-PRF) following Leukocyte-Platelet Rich Fibrin (L-PRF) on maxillary canine retraction: split-mouth randomized controlled trial.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the efficacy of injectable platelet-rich fibrin (i-PRF) following autologous leukocyte platelet-rich fibrin (L-PRF) placement on retraction of maxillary canine, and RANKL and OPG expression in gingival crevicular fluid (GCF) during comprehensive orthodontic treatment. Materials and methods: Sixteen subjects (age range, 18-25 years) requiring all 1st premolar extractions were enrolled. L-PRF plugs were placed in both maxillary 1st premolar extraction sockets. The i-PRF was injected submucosally after 4-weeks of L-PRF placement on the experimental sides. Canine retraction was initiated immediately after 1st premolars extraction and L-PRF placement using NiTi closed coil springs. Amount of canine retraction was evaluated from the study models prepared immediately before the 1st premolars extraction and 4-weeks, 8-weeks and 12-weeks after the start of canine retraction. The RANKL and OPG levels in GCF were measured immediately before the 1st premolars extraction and at 4-weeks, 6-weeks, 8-weeks, 10-weeks and 12-weeks after the beginning of canine retraction. Results: Over 12-weeks period, significantly greater amount of canine retraction was observed on experimental (4.77 ± 0.35 mm) sides compared to control (3.6 ± 0.48 mm) (P < 0.001). On experimental sides, a significant increase in the RANKL (P < 0.001) and decrease in the OPG levels (P < 0.001) were observed. In control sides, there was a negative, and in experimental sides, a positive correlation between the amount of canine retraction and RANKL and OPG levels in the GCF. Conclusion: Injection of i-PRF after 4-weeks of L-PRF application significantly enhanced the amount of canine movement and modulated bone metabolism by increasing RANKL and decreasing OPG levels in GCF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.