Evidence map›Paper›PMID 42569412›Full record

ArticleAutophagy reports2026

Retinal ganglion cell autophagy: a housekeeper essential for neuronal homeostasis and survival.

Yogapriya Sundaresan, Gulab S Zode

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yogapriya SundaresanGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.
Gulab S ZodeGavin Herbert Eye Institute- Brunson Center for Translational Vision Research, Department of Ophthalmology and Visual Sciences, University of California, Irvine, CA, USA.

Funding

Crosstalk Between Unfolded Protein Response and Autophagy for the Treatment of GlaucomaR01EY026177 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2016 to 2025
$3.8M
Novel Genome Editing for the Treatment of GlaucomaR01EY030366 · NEI · UNIVERSITY OF IOWA · PI CLARK, ABBOT FREDERICK, SHEFFIELD, VAL C. · 2019 to 2023
$2.7M
Impaired TRVP4-eNOS signaling in TM contributes to glaucomaR01EY034238 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Swapnil K. Sonkusare, Gulab Zode · 2022 to 2026
$2.2M
NEI NIH HHS R01 EY026177NEI NIH HHS R01 EY030366NEI NIH HHS R01 EY034238
6 · The paper itself

Abstract

Retinal ganglion cells (RGCs) are the sole projection neurons of the retina and the only direct link between retinal circuitry and the brain. Maintaining this lifelong connection requires constitutive autophagy to preserve organelle quality control and neuronal homeostasis. Although autophagy has been widely studied following ocular hypertension and optic nerve injury, its physiological role in healthy RGCs has remained unclear. We have recently revealed that basal autophagy is highly active in RGCs and that conditional deletion of

Indexed as

ATG5ATG7autophagyconditional knockoutneurodegenerationneuronal homeostasisorganelle accumulationretinal ganglion cells

Identifiers

PMID42569412
PMCPMC13449729

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.