ReviewFrontiers in medicine2026
The role and signal pathways of opsin 3 in the skin: from light perception to pathophysiological mechanisms.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Opsins are a class of classic G-protein-coupled receptor superfamily members, traditionally known to play a central role in phototransduction in the retina. Recent studies have revealed that various opsins are widely expressed in the skin, making the skin an important peripheral light-sensing organ. Among these, opsin 3 (OPN3), as one of the most abundantly expressed and functionally diverse photosensitive proteins in mammalian skin, has attracted increasing attention. This narrative review systematically outlines the expression profile of OPN3 among photoreceptors in the skin. Building on this, it provides a detailed analysis of OPN3's molecular structural characteristics, the mechanisms by which it detects light signals (particularly ultraviolet and short-wavelength visible light), and the downstream signal pathways it triggers in various skin cell types (such as keratinocytes, melanocytes and fibroblasts). These pathways include, but are not limited to, the G protein-mediated PLC-IP3/DAG-Ca
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