ArticleJournal of substance abuse and alcoholism2026
Carfentanil Depresses Inspiratory Motor Drive.
Article in Journal of substance abuse and alcoholism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Carfentanil exposure could cause severe ventilatory depression associated with muscle stiffness, hypoxemia/hypercapnia (due to hypoventilation) and hypothermia; however, its effect on inspiratory motor drive alone (without these associated effects) has not been investigated. This, along with the inhibitory impact of opioids on hypoxic and hypercapnic ventilation, allows us to determine the impacts of carfentanil on the phrenic nerve (PN) activities before and during hypoxia and hypercapnia in this study. Two groups of anesthetized and spontaneously breathing rats were initially exposed to aerosolized vehicle (Ctrl) and carfentanil (1.7 mg/m
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