ReviewCureus2026
Hantavirus Cluster Linked to Cruise Ship Travel: A Comprehensive Review of a Looming Global Public Health Concern.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hantaviruses are globally distributed, rodent-borne orthohantaviruses that cause hemorrhagic fever with renal syndrome in Eurasia and hantavirus cardiopulmonary syndrome (hantavirus pulmonary syndrome) in the Americas. Human infection usually results from environmental spillover through inhalation of aerosolized rodent excreta. However, the 2026 Andes virus (ANDV) cluster linked to the MV Hondius expedition cruise ship demonstrated how international travel networks can transform a rare zoonosis into a complex public health challenge. Following the Scale for the Assessment of Narrative Review Articles framework, this review synthesizes literature from 2019 to 2026 using explicit Boolean search strategies ("hantavirus" OR "orthohantavirus" OR "Andes virus" OR "ANDV") AND ("cruise" OR "maritime health" OR "shipboard medicine" OR "travel medicine" OR "outbreak response" OR "One Health") to evaluate global health governance and maritime outbreak preparedness. Unlike other human-pathogenic hantaviruses, ANDV is uniquely capable of limited person‑to‑person transmission through close, prolonged contact. Epidemiological investigation of the 2026 cluster confirmed that index cases were exposed during pre-embarkation terrestrial travel in highly endemic rural regions of Argentina and Chile, later manifesting on board. Clinically, hantavirus infection is characterized by severe endothelial dysfunction, capillary leak, and abrupt cardiopulmonary or renal failure following a nonspecific febrile prodrome. In the absence of curative antivirals or licensed vaccines, management depends on early risk recognition supported by a tiered diagnostic framework: rapid field-ready complete blood counts detecting thrombocytopenia and hemoconcentration to trigger stabilization and evacuation, followed by definitive molecular confirmation at centralized reference laboratories. The MV Hondius incident thus represents an operational biosecurity stress test rather than a pandemic threat, underscoring the need for integrated One Health surveillance, standardized maritime health governance, and legally codified protections for crew mental health and labor equity during isolation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.