Evidence map›Paper›PMID 42569311›Full record

ArticleSynthetic and systems biotechnology2027

Reassigning an amber codon to selenocysteine using a functional cysteine suppression pair in

Shaopeng Niu, Jingyan Wei, Mengna Li, Borui Guo, Qi Yan, Yu Huang, Zhenyan Jiang, Jian Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synthetic and systems biotechnology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaopeng NiuSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Jingyan WeiSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Mengna LiSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Borui GuoSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Qi YanSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Yu HuangSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Zhenyan JiangSchool of Pharmaceutical Science, Jilin University, Changchun, 130021, PR China.
Jian SongSchool of Microelectronics, Shanghai University, Shanghai, 201800, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenoproteins, characterized by the presence of selenocysteine (Sec) residues, are widely distributed across all domains of life. The unique attributes of selenoproteins are conferred by Sec, which is genetically encoded into nascent polypeptide chains through the recoding of the UGA codon. Human glutathione peroxidase 1 (GPx1) is a selenoprotein, which plays a crucial role in maintaining redox homeostasis. However, its complex recoding mechanism presents a major challenge for efficient selenoprotein expression in

Indexed as

Amber suppressionGenetic code expansionGlutathione peroxidaseSelenoprotein

Identifiers

PMID42569311
PMCPMC13449415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.