Evidence map›Paper›PMID 42569234›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Parallel neuroinflammatory pathways to cerebrovascular burden and amyloid beta in Alzheimer's disease.

Batool Rizvi, Jenna N Adams, Alison Bamford, Soyun Kim, Mithra Sathishkumar, Nicholas J Tustison, Lisa Taylor, Nandita Tuteja, Liv McMillan, Bin Nan and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Batool RizviCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Jenna N AdamsCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Alison BamfordDepartment of Neurobiology and Behavior University of California Irvine California USA.
Soyun KimCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Mithra SathishkumarCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Nicholas J TustisonCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Lisa TaylorCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Nandita TutejaCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Liv McMillanCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Bin NanDepartment of Epidemiology and Biostatistics University of California Irvine California USA.
Hengrui CaiDepartment of Statistics University of California Irvine California USA.
Yuritza Y EscalanteCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Novelle J MezaCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Alyssa L HarrisCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Rond MalhasCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain College of Physicians and Surgeons Columbia University New York New York USA.
Mark MapstoneCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.
Elizabeth A ThomasDepartment of Neurobiology and Behavior University of California Irvine California USA.
Michael A YassaCenter for the Neurobiology of Learning and Memory University of California Irvine California USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUpstream neuroinflammation plays an important role in Alzheimer's disease (AD) but remains poorly understood. We tested whether two distinct neuroinflammatory markers are associated with cerebrovascular burden and amyloid beta (Aβ), and downstream, with plasma phosphorylated tau (p-tau217), medial temporal lobe (MTL) cortical and hippocampal atrophy, and memory deficits.

methodsCognitively unimpaired older adults without dementia or mild cognitive impairment were recruited from a community sample (Biomarker Exploration in Aging, Cognition, and Neurodegeneration; [BEACoN];

resultsHigher plasma YKL-40 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F-florbetapir (FBP) standardized uptake value ratio (SUVR). Higher plasma GFAP, WMH, and FBP SUVR were independently associated with increased p-tau217. Plasma p-tau217 was associated with reduced MTL cortical thickness and hippocampal volume. Reduced hippocampal volume was related to worse memory. DISCUSSION: Future work can further investigate these neuroinflammatory pathways as potential therapeutic targets for AD.

Indexed as

agingAlzheimer's diseaseamyloid‐betacerebrovascular diseaseglial fibrillary acidic protein (GFAP)memorywhite matter hyperintensities (WMHs)YKL‐40

Identifiers

PMID42569234
PMCPMC13449296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.