ArticleFrontiers in nutrition2026
Postoperative enteral nutrition timing and risk variation in elderly patients with perforated peptic ulcer.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Enteral nutrition (EN) is important for postoperative recovery in elderly patients with perforated peptic ulcer (ePPUs), but the optimal initiation timing remains unclear. This study aimed to analyze the association between EN timing and adverse outcome in ePPUs. Methods: This retrospective cohort study enrolled 142 ePPUs who underwent surgical repair between May 2017 and May 2025. Postoperative outcomes were stratified using a two-step clustering (TSC) model. Subsequently, machine learning was further applied to evaluate how the risk of adverse outcomes varied with delayed enteral nutrition initiation. Results: Among 142 patients, 104 were classified into the NAOG and 38 into the AOG. Compared with the NAOG, the AOG showed higher rates of intra-abdominal infection (86.8% vs. 0.0%, Conclusion: Delayed postoperative EN initiation was associated with a cumulative increase in adverse outcome risk, which appeared to shift to a higher-risk level after approximately postoperative day 6.
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