Evidence map›Paper›PMID 42569184›Full record

ArticleACS organic & inorganic Au2026

Planar Chirality Directs Enantiospecific Diastereoselectivity in Isocyanide-Based Multicomponent Reactions.

Michael Kapsalis, Michael Fragkiadakis, Iakovos Konstantaras, Konstantinos G Froudas, Taxiarchis Stergiannakos, Rongyu Sun, Erica Benedetti, Constantinos G Neochoritis

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Article in ACS organic & inorganic Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael KapsalisChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.
Michael FragkiadakisChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.
Iakovos KonstantarasChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.
Konstantinos G FroudasChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.
Taxiarchis StergiannakosChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.
Rongyu SunLaboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Université Paris Cité, CNRS, F-75006 Paris, France.
Erica BenedettiLaboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Université Paris Cité, CNRS, F-75006 Paris, France.ORCID https://orcid.org/0000-0002-6457-7381
Constantinos G NeochoritisChemistry Department, University of Crete, Voutes, 70013 Heraklion, Greece.ORCID https://orcid.org/0000-0001-5098-5504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stereochemical control in isocyanide-based multicomponent reactions (IMCRs) remains a fundamental challenge, particularly in substrate-controlled variants. Here we show that planar chirality embedded within [2.2]-paracyclophane scaffolds enables predictable enantiospecific stereochemical transfer across the Passerini three-component reaction as well as the Ugi four-component and Ugi-tetrazole manifolds. Each enantiomer of the planar-chiral substrate stereospecifically transfers its configuration to the product, establishing a deterministic relationship between substrate and product stereochemistry. Across more than 65 reactions, this strategy provides consistent diastereocontrol without external chiral catalysts. These findings establish planar chirality as a general substrate-encoded principle for stereochemical control in IMCRs and expand the scope of enantiospecific multicomponent synthesis beyond classical point chirality.

Indexed as

[2.2]Paracyclophanesdiastereoselectivitymulticomponent reactionspasserini reactionplanar chiralityugi reaction

Identifiers

PMID42569184
PMCPMC13449445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.