Evidence map›Paper›PMID 42569161›Full record

ArticleACS organic & inorganic Au2026

Diastereoselective Synthesis of α‑Fluoro-γ-lactams via Difluorocarbene-Triggered Cyclization and Rearrangement.

Maryam Jabbarpoor, Yanmei Li, Alex Akhundov, Jesse LeBlanc, Pier Alexandre Champagne, Christine M Le

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS organic & inorganic Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maryam JabbarpoorDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.
Yanmei LiDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, New Jersey 07102, United States.
Alex AkhundovDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.ORCID https://orcid.org/0009-0003-6676-9795
Jesse LeBlancDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.ORCID https://orcid.org/0000-0002-1864-5646
Pier Alexandre ChampagneDepartment of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, New Jersey 07102, United States.ORCID https://orcid.org/0000-0002-0546-7537
Christine M LeDepartment of Chemistry, York University, Toronto, ON M3J 1P3, Canada.ORCID https://orcid.org/0000-0003-2543-4414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a difluorocarbene-enabled, diastereoselective synthesis of α-fluoro-γ-lactams from readily accessible β-aminoketones and inexpensive, commercially available ethyl bromodifluoroacetate (EBDFA). Compared to established routes to this medicinally relevant motif, our strategy avoids the use of costly electrophilic fluorinating or deoxyfluorinating reagents, highlighting difluorocarbene as a versatile C1 and F building block. Density functional theory (DFT) calculations reveal that cyclization is the stereodetermining step, with observed diastereomeric ratios governed by Curtin-Hammett kinetics. In addition to activating EBDFA, the K

Indexed as

cyclizationdiastereoselectivitydifluorocarbenefluorinelactam

Identifiers

PMID42569161
PMCPMC13449420

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.