Evidence map›Paper›PMID 42568956›Full record

ArticleACS omega2026

Evaluation of Chalcone (

José Ivo Lima Pinto Filho, Francisco Nithael Melo Lucio, Lyanna Rodrigues Ribeiro, Matheus Nunes da Rocha, Hélcio Silva Dos Santos, Francisco Wagner de Queiroz Almeida-Neto, Emanuel Paula Magalhaes, Alice Maria Costa Martins, Ramon Róseo Paula Pessoa Bezerra de Menezes, Márcia Machado Marinho and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

José Ivo Lima Pinto FilhoDepartment of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.
Francisco Nithael Melo LucioDoctoral Program in Biotechnology, Northeast Biotechnology Network, State University of Ceará, Fortaleza, Ceará 60714-903, Brazil.ORCID https://orcid.org/0000-0002-3652-1102
Lyanna Rodrigues RibeiroDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.ORCID https://orcid.org/0000-0003-1576-6167
Matheus Nunes da RochaPostgraduate Program in Natural Sciences, Sciences and Technology Center, State University of Ceará, Fortaleza, Ceará 60714-903, Brazil.ORCID https://orcid.org/0000-0002-0929-4565
Hélcio Silva Dos SantosPostgraduate Program in Natural Sciences, Sciences and Technology Center, State University of Ceará, Fortaleza, Ceará 60714-903, Brazil.ORCID https://orcid.org/0000-0001-5527-164X
Francisco Wagner de Queiroz Almeida-NetoCenter for Education, Science and Technology of the Inhamuns Region, State University of Ceará, Tauá, Ceará 60714-903, Brazil.ORCID https://orcid.org/0000-0003-3317-5029
Emanuel Paula MagalhaesDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.
Alice Maria Costa MartinsDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.
Ramon Róseo Paula Pessoa Bezerra de MenezesDepartment of Clinical and Toxicological Analysis, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.ORCID https://orcid.org/0000-0003-3109-9683
Márcia Machado MarinhoPostgraduate Program in Natural Sciences, Sciences and Technology Center, State University of Ceará, Fortaleza, Ceará 60714-903, Brazil.
Pedro De Lima-NetoDepartment of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.ORCID https://orcid.org/0000-0002-1613-4797
Emmanuel Silva MarinhoDepartment of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, Fortaleza, Ceará 60355-636, Brazil.ORCID https://orcid.org/0000-0002-4774-8775

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease (CD), once found mainly in underdeveloped countries, is becoming a public health problem in the developed world. Although the drug benznidazole (BZN) is effective in the acute phase of the disease, it causes toxicity due to the formation of reactive substances resulting from presystemic metabolism, which have the ability to bind to DNA structures. This study conducts experimental tests with the epimastigote and trypomastigote species of the parasite, followed by drug-target interaction analyses through molecular docking against the enzymes trypanothione reductase, cruzain, and TcGAPDH, as well as pharmacokinetic prediction based on MPO analyses. In vitro tests revealed CPN4F's significant efficacy in reducing host cell viability and inhibiting parasite growth. Molecular docking indicated CPN4F's favorable energy ordering and superiority to BZN against the cruzain target (Δ

Identifiers

PMID42568956
PMCPMC13448934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.