Evidence map›Paper›PMID 42568901›Full record

ArticleOpen forum infectious diseases2026

Pediatric Hemolytic Uremic Syndrome in North-Eastern Germany During the STEC O45:H2 Outbreak in 2025: Clinical Features and Short-Term Outcomes.

Lea M Merz, Katja Doerry, Florian Buerger, Verena Klämbt, Moritz Boeckelmann, Katalin Dittrich, Emilia Marczak, Michael Pohl, Maria Heyde, Keike Paulsen and 12 more

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Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lea M MerzDepartment of Pediatric Nephrology, University Hospital Leipzig, Leipzig, Germany.ORCID https://orcid.org/0009-0005-6000-6791
Katja DoerryPediatric Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Florian BuergerPediatric Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Verena KlämbtDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin-Campus Virchow Klinikum, Berlin, Germany.
Moritz BoeckelmannDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin-Campus Virchow Klinikum, Berlin, Germany.
Katalin DittrichDepartment of Pediatric Nephrology, University Hospital Leipzig, Leipzig, Germany.
Emilia MarczakDepartment of Pediatric Nephrology, University Hospital Leipzig, Leipzig, Germany.
Michael PohlKfH Kidney Center for Children and Adolescents, St Georg Hospital, Leipzig, Germany.
Maria HeydeDepartment of Pediatric Nephrology, University Hospital Carl Gustav Carus, Dresden, Germany.
Keike PaulsenPediatric Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jens DrubeDepartment of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical School, Hannover, Germany.ORCID https://orcid.org/0009-0009-4565-6664
Heimke von OstenDepartment of Pediatrics, University Hospital Greifswald, Greifswald, Germany.
Hagen StaudeDepartment of Pediatric Nephrology, University Children's Hospital Rostock, Rostock, Germany.
Alexander MellmannInstitute of Hygiene and National Consulting Laboratory for Hemolytic Uremic Syndrome (HUS), University Hospital Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-0649-5185
Johannes HolleUniversity Children's Hospital, University Hospital Tübingen, Tübingen, Germany.
Christina LangDepartment of Infectious Diseases, National Reference Center (NRC) for Salmonella and Other Enteric Pathogens, Robert Koch Institute, Branch Wernigerode, Germany.ORCID https://orcid.org/0009-0007-8157-6325
Angelika FruthDepartment of Infectious Diseases, National Reference Center (NRC) for Salmonella and Other Enteric Pathogens, Robert Koch Institute, Branch Wernigerode, Germany.
Tanja Jung-SendzikDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Julia ThumfartDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin-Campus Virchow Klinikum, Berlin, Germany.
Jun OhPediatric Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Raphael SchildPediatric Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Dominik MüllerDepartment of Pediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité Universitätsmedizin Berlin-Campus Virchow Klinikum, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Shiga toxin-producing Methods: We retrospectively included all pediatric STEC-HUS cases treated in Northeastern Germany during the outbreak period. Microbiological confirmation was performed through cultivation and molecular typing at the National Reference and Consulting Laboratories. Patients were classified as O45:H2 or non-O45:H2 based on serotyping and the Robert Koch Institute (RKI) O45:H2 outbreak case definition. Clinical and laboratory parameters, dialysis requirements, transfusion needs, and short-term outcomes were compared. Results: Thirty-seven children with STEC-associated HUS were included: 18 with O45:H2 and 19 with other serotypes. Patients with O45:H2 were significantly younger (median 2.0 vs 4.0 years, Conclusions: O45:H2-associated HUS was comparable in severity to non-O45:H2 STEC-HUS, while the younger age of affected children may indicate distinct host susceptibility or exposure patterns.

Indexed as

childrenhemolytic uremic syndromeserotype O45:H2Shiga toxin–producing E. coliSTEC

Identifiers

PMID42568901
PMCPMC13448724

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.