ArticleJournal of orthopaedic translation2026
LIPUS combined with mild hyperthermia promotes rotator cuff healing via TRPV1/Ca
Article in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Background: Rotator cuff injuries often lead to impaired shoulder function, and tendon-bone healing remains challenging due to the complex structure of the enthesis and persistent remodeling-associated pro-inflammatory signaling. Low-intensity pulsed ultrasound (LIPUS) and mild hyperthermia (MH) have shown potential in tissue repair, but the molecular mechanisms underlying their combined effects are unclear. Objective: This study aimed to investigate whether LIPUS and MH synergistically promote tendon-bone healing by regulating macrophage polarization through the TRPV1/Ca Methods: A rabbit supraspinatus tendon-bone injury model and in vitro macrophage polarization assays were employed. Histology, immunohistochemistry, MRI, and biomechanical testing were performed to assess repair outcomes. RNA-seq with qPCR and Western blot validation was used to identify key signaling pathways. Functional assays, including Ca Results: LIPUS and MH significantly suppressed M1 polarization (CD86, iNOS) and enhanced M2 markers (CD163, Arg1), reducing ROS levels and inflammatory cytokine expression. Combined intervention yielded the most pronounced effects, showing improved fibrocartilage formation, collagen alignment, and bone remodeling, with superior biomechanical strength approaching native tissue. Transcriptomic and protein analyses revealed increased TRPV1 activation, enhanced Ca Conclusion: Combined LIPUS and MH synergistically enhance tendon--bone healing, potentially through modulating the TRPV1/Ca The translational potential of this article: This study identifies the TRPV1/Ca
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