ArticleJournal of the Korean Society of Radiology2026
Indications for Core Needle Biopsy in Low-Suspicion Thyroid Nodules on US.
Article in Journal of the Korean Society of Radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: This study aimed to identify the appropriate clinical indications for core needle biopsy (CNB) in low-suspicion nodules (Korean Thyroid Imaging Reporting and Data System category 3) by assessing the US features associated with CNB-based diagnoses of malignancy and surgically relevant disease. Materials and Methods: Between January 2018 and December 2019, 910 thyroid nodules from 903 patients underwent US-guided CNB. Among these, 271 patients with low-suspicion thyroid nodules on US who later underwent surgery were included in this study. The nodules were dichotomized into two categories: malignancy (including low-suspicion neoplasms) and surgical disease (categorized as follicular neoplasm, suspicious for malignancy, or malignancy on CNB). Hypervascularity was defined as types 3 or 4. Results: The malignancy rate of resected low-suspicion nodules was found to be 36.5%. In low-suspicion nodules, a well-defined halo and hypervascularity were independent risk factors associated with malignancy (odds ratio = 2.06, 95% confidence interval [CI] = 1.11-3.83, Conclusion: Targeting low-suspicion thyroid nodules with a well-defined halo and hypervascularity observed on US may provide supplementary diagnostic value in identifying nodules associated with malignancy and surgical disease using CNB.
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