ArticleProgress in rehabilitation medicine2026
Eight-year Progression of Locomotive Syndrome in Community-dwelling Older Adults: The Obuse Study.
Article in Progress in rehabilitation medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
Objectives: Longitudinal evidence on Locomotive Syndrome (LoS) progression in community-dwelling older adults remains limited. We examined 8-year transitions in LoS stages in a population-based Japanese cohort. Methods: Between 2014 and 2017, 415 residents aged 50-89 years were randomly enrolled. LoS stage (0-3) was assessed at baseline and at follow-up using Japanese Orthopaedic Association criteria, based on the 25-question Geriatric Locomotive Function Scale and standard performance tests. Follow-up data were available for 169 participants (40.7%) after a mean interval of 8.46 years. Baseline characteristics were compared between participants and non-participants. Stage transitions were analyzed according to baseline age, sex, and LoS stage. To address attrition bias, a multivariable model for follow-up participation, inverse probability weighting (IPW), and scenario-based sensitivity analyses were applied. Results: Advanced LoS (Stage 2 or 3) increased from 8.8% to 30.2%, indicating significant overall progression (P <0.001). Transitions were heterogeneous, with some improvement. The proportion of participants with worsening increased with age, ranging from 19.0% [95% confidence interval (CI) 10.2%-30.9%] among those aged 50-59 years to 66.7% (95% CI 34.9%-90.1%) among those aged 80-89 years. Among participants with baseline Stages 0-2, baseline Stage 0 (vs Stage 1) and older age were independently associated with worsening. Participants were younger and fitter than non-participants. Worsening was 37.3% in complete cases and 40.1% after IPW; advanced LoS at follow-up increased from 30.2% to 42.2% after IPW. Conclusions: LoS stages progressed substantially over 8 years, with a marked increase in advanced LoS. Because follow-up participation was selective, these estimates likely underestimate the true burden in the original cohort.
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