ArticleHealth science reports2026
Two-Point Change Patterns of LDL-Cholesterol and hs-CRP and Risk of Major Adverse Cardiovascular Events in Middle-Aged and Older Chinese Adults: A Prospective Cohort Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: The associations of two-point change patterns of low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) with major adverse cardiovascular events (MACE) remain underexplored, particularly in Chinese populations. This study aimed to identify LDL-C and hs-CRP change patterns and examine their associations with incident MACE in middle-aged and older Chinese adults. Methods: This prospective cohort study included 9597 participants aged 45 years or older and free of cardiovascular disease at baseline from the China Health and Retirement Longitudinal Study. Among them, 6405 participants with biomarker measurements available in both 2011 and 2015 were included in the two-point change pattern analysis. Group-based trajectory modeling was used to identify two-point change pattern groups for LDL-C and log-transformed hs-CRP. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with adjustment for potential confounders including lipid-lowering medication use. Results: Over a median follow-up of 9.00 years, 2248 participants (23.4%) developed MACE. Higher baseline hs-CRP levels were associated with increased MACE risk, with a significant association observed for the fourth quintile versus the first quintile (HR = 1.19, 95% CI: 1.04-1.36). In the two-point change pattern analysis, the Conclusion: Baseline hs-CRP showed a stronger association with MACE than LDL-C after comprehensive adjustment. A decrease in hs-CRP from a high baseline level was associated with a lower HR estimate for MACE, although this finding was not statistically significant. These results support the relevance of inflammatory status in cardiovascular risk assessment, while LDL-C monitoring remains a cornerstone of cardiovascular prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.