ArticleFrontiers in psychiatry2026
Association between the triglyceride to high-density lipoprotein cholesterol ratio and 90-day post-stroke depression in acute ischemic stroke.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Post-stroke depression (PSD) commonly complicates acute ischemic stroke (AIS), with insulin resistance (IR)-mediated metabolic disturbances proposed as an underlying pathophysiological link. The triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL)-a validated, cost-effective surrogate for IR-has preliminary associations with depressive symptoms. However, the relationship between TG/HDL and the risk of PSD in patients with AIS remains unclear. Methods: A cohort of 519 AIS patients was retrospectively analyzed (October 2023-December 2024). The primary outcome was 90-day PSD, diagnosed via the HAMD-24 (score > 7). Multivariable logistic regression assessed the independent association between admission TG/HDL and PSD. Nonlinear associations were assessed using restricted cubic splines (RCS). Results: Thirty-three point nine percent of patients developed PSD. The TG/HDL ratio was an independent predictor of PSD (Model 3: OR = 1.5634, 95% CI: 1.0097-2.4281, Conclusions: Admission TG/HDL ratio was independently associated with 90-day PSD, suggesting that it may serve as a convenient metabolic marker for identifying patients at higher risk of developing PSD. The observed non-linear pattern requires cautious interpretation and validation in larger prospective cohorts.
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