ArticleBrain & NeuroRehabilitation2026
Emergence From Minimally Conscious State Following Addition of Zolpidem to Amantadine Therapy in a Patient With Preserved Cortical Metabolism After Subarachnoid Hemorrhage: A Case Report.
Article in Brain & NeuroRehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report the case of an 80-year-old female patient with subarachnoid hemorrhage who demonstrated marked improvement in the Coma Recovery Scale-Revised (CRS-R) score following the addition of zolpidem to amantadine therapy. Brain positron emission tomography-computed tomography demonstrated diffuse cerebral hypometabolism with relatively preserved fronto-parietal cortical uptake, suggesting preserved cortical metabolic activity. After initiating zolpidem 10 mg and escalating amantadine to 200 mg/day, the patient's CRS-R score increased from 12 to 19 within three days, corresponding to emergence from a minimally conscious state. This case suggests that preserved cortical metabolic activity may be associated with the additive or synergistic effects of pharmacological arousal therapy in disorders of consciousness in non-Traumatic Brain Injury patients.
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