Evidence map›Paper›PMID 42568599›Full record

ArticleFrontiers in immunology2026

Agent-specific training directs distinctive immune response against

Marie Kim, Hailey G Main, Aaron P Esser-Kahn

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marie KimPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
Hailey G MainDepartment of Chemistry, University of Chicago, Chicago, IL, United States.
Aaron P Esser-KahnPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.

Funding

Discovery of adjuvants via novel modulation of innate immune pathways for vaccines against influenza75N93019C00041 · NIAID · UNIVERSITY OF CHICAGO · PI ESSER-KAHN, AARON · 2019 to 2024
$10.0M
DEVELOPMENT OF VACCINES FOR INFLUENZA USING AN IMMUNO-MODULATOR ADJUVANT AND MULTI-PLATFORM APPROACH75N93023C00044 · NIAID · UNIVERSITY OF CHICAGO · PI EL-KAMMASH, BRUXANNE · 2023 to 2025
$7.3M
Development of a recombinant protein vaccine for Chlamydia trachomatisU01AI182180 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Toni Darville, Aaron P Esser-Kahn · 2024 to 2026
$5.8M
NIAID NIH HHS U01 AI182180NIH HHS 75N93019C00041NIH HHS 75N93023C00044
6 · The paper itself

Abstract

The nonspecific protection provided by the innate immune system can be enhanced through training with stimuli, a phenomenon called 'trained immunity'. However, it remains unknown if distinct training programs with various functional outcomes can be induced. Here, we show that two training agents, flunisolide and myricetin, distinctively train and modulate the immune response against

Indexed as

FlavonoidsImmunity, InnateListeria monocytogenesListeriosisAnimalsAntigen PresentationMiceMice, Inbred C57BLPhagocytosisTrained ImmunityFlavonoidsmyricetinflunisolideinfectioninnate immune memorymyricetintrained immunity

Identifiers

PMID42568599
PMCPMC13447383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.