Evidence map›Paper›PMID 42568480›Full record

ArticleInternational journal of heart failure2026

Ischemic Evaluation and Long-Term Mortality in New-Onset Heart Failure Across Various Age-Groups.

Alan Manivannan, Morten Schou, William E Boden, Emil Fosbøl, Lars Køber, Gunnar H Gislason, Kevin Monahan, Christian Torp-Pedersen, Charlotte Andersson

Abstract read
In one paragraph

Article in International journal of heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alan ManivannanSection of Internal Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9117-8554
Morten SchouDepartment of Cardiology, Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark.ORCID https://orcid.org/0000-0002-1274-5072
William E BodenVA New England Healthcare System, Boston University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0001-7145-8084
Emil FosbølThe Heart Centre, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-2048-4167
Lars KøberThe Heart Centre, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6635-1466
Gunnar H GislasonDepartment of Cardiology, Herlev and Gentofte Hospital, Copenhagen University, Gentofte, Denmark.ORCID https://orcid.org/0000-0002-0548-402X
Kevin MonahanSection of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0001-7483-2238
Christian Torp-PedersenSteno Diabetes Center, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2892-6131
Charlotte AnderssonDepartment of Cardiology, Herlev and Gentofte Hospital, Copenhagen University, Herlev, Denmark.ORCID https://orcid.org/0000-0001-6019-8627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: The prognostic significance of ischemic evaluation in patients with new-onset heart failure is not well understood and may differ according to age and sex. In a real-world cohort, we analyzed the long-term mortality risk after undergoing an ischemic evaluation. Methods: All new-diagnosed heart failure patients 2008-2018 without prior ischemic evaluation, known coronary artery disease, or acute myocardial infarction were identified from the Danish National patient registry. The association of an ischemic evaluation within 90 days of heart failure diagnosis with long-term mortality was analyzed by inverse probability weighted Cox regression models. Results: A total of 61,475 patients were included (mean age 73.3±13.9 years, 46% women), of which 12,503 (20%) underwent an ischemic evaluation. During a mean follow-up of 4.6 years, 37% of patients died, corresponding to a mortality rate of 8.0 (7.9-8.1) per 100 person-years. The multivariable-adjusted hazard ratio of death was 0.92 (95% confidence interval, 0.90-0.95) for patients who underwent ischemic evaluation, compared with patients who did not. An ischemic evaluation was associated with a lower hazard ratio in males than females: 0.87 (0.84-0.90) vs. 0.98 (0.94-1.02), and in middle-aged vs. older or younger individuals: 0.91 (0.75-1.12) in patients ≤50 years, 0.82 (0.72-0.93) in 51-60 years, 0.83 (0.79-0.87) in 61-75 years, 0.93 (0.88-0.97) in >75-85 years, and 1.02 (0.97-1.07) in >85 years, respectively. Conclusions: Obtaining an ischemic evaluation was associated with marginal to no improvement in long-term mortality for many new-diagnosed heart failure patients, including the very elderly.

Indexed as

Heart failureIschemic evaluationMortality risk

Identifiers

PMID42568480
PMCPMC13447194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.