ArticleFrontiers in oncology2026
Oxygen-enhanced MRI in patients with uterine cervical carcinoma: feasibility and treatment-associated changes in tumour oxygen-enhanced response.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Tumour hypoxia causes resistance against radiotherapy and chemotherapy in locally advanced cervical cancer (LACC). Non-invasive magnetic resonance imaging (MRI) biomarkers have the potential to guide hypoxia-targeted therapy but require technical development and validation. This study evaluated the feasibility and early treatment response monitoring capabilities of oxygen-enhanced MRI (OE-MRI) in healthy female volunteers and patients with LACC. Methods: Healthy volunteers underwent OE-MRI to demonstrate the feasibility of the technique and to compare the onset, magnitude, and duration of change in longitudinal relaxation rate (Δ Results: Feasibility was demonstrated in 97% (31/32) of uterine tissue regions of interest, measured in 18 volunteers. Δ Conclusion: This first dedicated OE-MRI study in cervical cancer shows technique feasibility in healthy volunteers and patients with LACC. Treatment-associated increases in tumour Δ
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