Case Report: a rare pediatric case series of multiple endocrine neoplasia type 2B presenting with laryngotracheal involvement.

Background: Multiple endocrine neoplasia type 2B (MEN2B) is a rare autosomal dominant genetic disorder caused by activating germline mutations in the Methods: From 2013 to 2025, two pediatric patients diagnosed with MEN2B were identified at our center. Both cases were confirmed to harbor pathogenic Result: In this study, we describe two pediatric cases of MEN2B in which laryngeal obstruction and progressive respiratory compromise were the initial clinical manifestations. Laryngoscope and CT examinations revealed mucosal neuromas within the laryngotracheal airway, and postoperative histopathology confirmed the diagnosis of neuroma. We further review the available literature on laryngotracheal involvement in MEN2B to elucidate its phenotypic spectrum and clinical implications. Timely recognition through detailed phenotypic assessment, molecular confirmation of Conclusion: Laryngeal or airway neuromas are extremely rare. Clinicians should maintain a high index of suspicion for laryngeal neuromas in children presenting with characteristic craniofacial dysmorphism or a family history suggestive of endocrine neoplasia, as prompt genetic evaluation and integrated management may be life-saving.