Evidence map›Paper›PMID 42568417›Full record

ArticleFrontiers in oncology2026

Case Report: Long-term survival in extensive-stage small cell lung cancer treated with adebrelimab-based combination therapy.

Yu Xia, Yuxian Yang, Wanzhong Huang, Yongshun Chen

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu XiaDepartment of Oncology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yuxian YangDepartment of Oncology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Wanzhong HuangDepartment of Oncology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yongshun ChenDepartment of Oncology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The integration of immune checkpoint inhibitors into first-line treatment has markedly improved outcomes for extensive-stage small cell lung cancer (ES-SCLC). Adebrelimab, a PD-L1 inhibitor, demonstrated superior overall survival in the phase 3 CAPSTONE-1 trial. We present a detailed case of a 62-year-old male with ES-SCLC who achieved a progression-free survival (PFS) of 33 months following a multimodal regimen of adebrelimab plus chemotherapy, consolidative thoracic radiotherapy, and maintenance immunotherapy. Despite low PD-L1 expression (TPS<1%), the patient exhibited profound and durable tumor regression, with the primary mass shrinking from 146×158×217 mm to 51×21 mm. Treatment was well-tolerated with only grade 1-2 adverse events. This report underscores the potential for long-term disease control with adebrelimab-based therapy even in biomarker-unselected populations and highlights the importance of combined modality strategies.

Indexed as

adebrelimabcase reportchemoimmunotherapyextensive-stagelong-term survivalPD-L1 inhibitorradiotherapysmall cell lung cancer

Identifiers

PMID42568417
PMCPMC13447168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.