ArticleFrontiers in nutrition2026
Changes in rectus femoris diameter: a cooperation-independent assessment method for ICU-acquired weakness.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: ICU-acquired weakness (ICUAW) affects 50-100% mechanically ventilated critically ill patients, prolonging ventilation and hospital stay and raising long-term mortality. Conventional assessments including MRC scale and handgrip test require alert, cooperative patients, whereas electromyography and muscle biopsy are invasive and unsuitable for repeated bedside use. Static muscle ultrasound only reflects muscle mass but cannot accurately reflect actual muscle function. Objective: This study aimed to develop a cooperation-free evaluation method combining bedside ultrasound and electrical stimulation to induce rectus femoris contraction, and verify its diagnostic performance for ICUAW. Methods: A total of 58 mechanically ventilated adult patients (aged ≥18 years, mechanical ventilation duration ≥5 days) were enrolled and divided into the ICUAW group ( Results: All static and dynamic muscle indicators were significantly lower in the ICUAW group ( Conclusion: Ultrasound-measured rest-contraction transverse diameter difference of rectus femoris (ΔRF-d, resting diameter minus contraction diameter) induced by electrical stimulation serves as a promising cooperation-independent marker to assess muscle strength and screen ICUAW in critical care.
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