Evidence map›Paper›PMID 42568179›Full record

ArticlePhysiological reports2026

Thirst and blood pressure regulation in a novel angiotensin II receptor type 1a knockout rat.

Caroline B Ferreira, Sean D Stocker

Abstract read
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Caroline B FerreiraDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-7611-0586
Sean D StockerDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-6317-6300

Funding

Forebrain electroneutral transporters in salt-sensitive hypertensionR01HL163906 · NHLBI · UNIVERSITY OF DELAWARE · PI SEAN D STOCKER, Megan M Wenner · 2023 to 2026
$2.8M
Identification of mechano versus chemo-sensitive renal sensory neurons in hypertensionR01HL152680 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2020 to 2023
$2.4M
Brain NaCl-sensing in salt-sensitive hypertension.R01HL145875 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2019 to 2022
$2.2M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL145875HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL152680HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL163906NHLBI NIH HHS R01 HL145875NHLBI NIH HHS R01 HL152680NHLBI NIH HHS R01 HL163906
6 · The paper itself

Abstract

Angiotensin II (AngII) plays a pivotal role in body fluid balance through AngII type 1 receptors (Agtr1) expressed in circumventricular organs to stimulate thirst. Blockade of central Agtr1 attenuates thirst to hypotension but not acute hypernatremia. Data in genetic knockout models are limited as systemic AngII does not stimulate thirst in mice, and Agtr1a

Indexed as

Blood PressureReceptor, Angiotensin, Type 1ThirstAngiotensin IIAnimalsMaleRatsRats, Sprague-DawleyAgtr1a protein, ratAngiotensin IIReceptor, Angiotensin, Type 1angiotensin IIangiotensin II receptorblood pressurehypotensionthirst

Identifiers

PMID42568179
PMCPMC13451629

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.