ArticleJournal of the American Heart Association2026
Intraplaque Hemorrhage in Chronic Anterior Circulation Arterial Occlusion: Associated Factors and Vessel-Specific Patterns on High-Resolution Magnetic Resonance Imaging.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic anterior circulation arterial occlusion, particularly involving the internal carotid artery or middle cerebral artery (MCA), carries a persistent risk of ischemic events. Intraplaque hemorrhage (IPH) is a marker of plaque instability, but its prevalence, vessel-specific distribution, and clinical correlates in chronic anterior circulation arterial occlusion remain unclear.
methodsWe retrospectively enrolled 210 patients with chronic anterior circulation arterial occlusion who underwent high-resolution magnetic resonance imaging between January 2024 and March 2025. IPH was identified by T1-weighted hyperintensity within the vessel wall. Clinical and vascular risk factors, imaging, and laboratory factors associated with IPH were analyzed using logistic regression, including analyses stratified by occlusion site.
resultsIPH was detected in 86 (41.0%) and was more frequent in internal carotid artery than MCA occlusion (60.5% versus 38.4%). Patients with IPH were more frequently male, had more smoking history, lower platelet counts, higher creatinine levels, and more recent acute ischemic stroke. In multivariable analysis, recent acute ischemic stroke (adjusted odds ratio [aOR], 2.08 [95% CI, 1.10-3.94]) and occlusion location (MCA versus internal carotid artery, aOR, 0.51 [95% CI, 0.27-0.95]) were independently associated with IPH. Intracranial internal carotid artery occlusion showed a lower likelihood of IPH in univariable analysis, with directionally consistent associations after adjustment (OR, 0.26 [95% CI, 0.09-0.79]), whereas recent acute ischemic stroke remained independently associated with IPH in MCA occlusion (aOR, 3.12 [95% CI, 1.19-8.20]).
conclusionsIPH is common in chronic anterior circulation arterial occlusion and shows vessel-specific patterns. Its association with recent ischemic stroke, particularly in MCA occlusion, suggests persistent plaque activity in some chronically occluded arteries. High-resolution magnetic resonance imaging may help characterize plaque phenotype and improve risk assessment in chronic occlusive cerebrovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.