Observational studyClinical oral investigations2026
Perception of patients with temporomandibular disorders of the effects of botulinum toxin application: a retrospective cross-sectional observational study.
Observational study in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
objectiveTo evaluate patient-reported changes in orofacial and masticatory symptoms after BoNT-A application in individuals presenting bruxism-related complaints. MATERIALS AND
methodsA retrospective cross-sectional observacional study was conducted with 61 adult participants (47 women, 14 men) who underwent BoNT-A treatment for bruxism. An online questionnaire, assessed masticatory and orofacial symptoms before and after treatment, using a five-point frequency scale. Data were analyzed with descriptive statistics, paired t-tests, and Spearman's correlation (p < 0.05). This observational study was reported in accordance with the STROBE guidelines.
resultsA statistically significant reduction in total symptom scores was observed after treatment (p < 0.05), with a mean decrease from 32.4 ± 11.5 (before) to 15.6 ± 6.59 (after), representing an overall reduction of approximately 52%. No significant differences in symptom improvement were observed between sexes or in relation to age. Although an overall difference among professional categories was identified, post hoc analysis did not show significant pairwise differences between groups.
conclusionIndividuals with bruxism-related complaints reported improvement in pain-related and masticatory symptoms after BoNT-A application. BoNT-A may represent a supportive approach for managing orofacial and muscle-related complaints; however, further studies with standardized diagnostic criteria and objective outcome measures are needed to clarify its long-term clinical effects. CLINICAL RELEVANCE: BoNT-A application may contribute to the management of pain-related and masticatory complaints reported by individuals with bruxism-related symptoms, supporting its potential use as an adjunctive approach in selected clinical situations.
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