Evidence map›Paper›PMID 42567924›Full record

ArticleThe EMBO journal2026

Allosteric switching of Ca

Qianru Mu, Ryo Saito, Franceska Ozola, Dawid Jaślan, Pak Nin Chu, Afroditi-Maria Zaki, Marcos Rubio-Alarcon, Marco Keller, Yu Yuan, Alan Greig and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qianru Mu *Department of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0009-0003-6748-5831
Ryo Saito *Department of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-1927-8147
Franceska OzolaDepartment of Cell and Developmental Biology, University College London, London, UK.
Dawid JaślanWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0002-0685-7633
Pak Nin ChuDepartment of Cell and Developmental Biology, University College London, London, UK.
Afroditi-Maria ZakiStructural Bioinformatics and Computational Biochemistry, Department of Biochemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-0992-9732
Marcos Rubio-AlarconDepartment of Pharmacology, University of Cambridge, Cambridge, UK.
Marco KellerDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0003-4792-3980
Yu YuanDepartment of Cell and Developmental Biology, University College London, London, UK.
Alan GreigDepartment of Cell and Developmental Biology, University College London, London, UK.
Virginia SilioDepartment of Cell and Developmental Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-3169-336X
Franz BracherDepartment of Pharmacy-Center for Drug Research, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0003-0009-8629
Philip C BigginStructural Bioinformatics and Computational Biochemistry, Department of Biochemistry, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5100-8836
Gabriela C BrailoiuDepartment of Pharmaceutical Sciences, Jefferson College of Pharmacy, Thomas Jefferson University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2512-6545
Eugen BrailoiuDepartment of Neural Sciences and Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Jonathan S MarchantDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0001-6592-0877
Christian GrimmWalther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilian University, Munich, Germany.ORCID http://orcid.org/0000-0002-0177-5559
Eric J LambieDepartment of Cell and Developmental Biology, University College London, London, UK.
Taufiq RahmanDepartment of Pharmacology, University of Cambridge, Cambridge, UK. mtur2@cam.ac.uk.ORCID http://orcid.org/0000-0003-3830-5160
Sandip PatelDepartment of Cell and Developmental Biology, University College London, London, UK. patel.s@ucl.ac.uk.ORCID http://orcid.org/0000-0001-7247-2013

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Functional architecture of IP3-evoked local Ca2+ signalsR01GM088790 · NIGMS · UNIVERSITY OF MINNESOTA · PI MARCHANT, JONATHAN S, SLAMA, JAMES T · 2009 to 2025
$4.7M
SARS-CoV-2 signaling and interactions with stimulant drugs of abuse via Sigma-1R: Impact on the BBBR01DA054921 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI Gabriela Cristina Brailoiu, ELLEN M UNTERWALD · 2022 to 2026
$2.4M
Deciphering the complex pharmacology of CB1: towards the understanding of a third signaling pathwayR21DA056729 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI BRAILOIU, EUGEN, WARD, SARA J · 2023 to 2024
$436k
Deutsche Forschungsgemeinschaft (DFG) ANR/DFGDeutsche Forschungsgemeinschaft (DFG) BR 1034/7-1Deutsche Forschungsgemeinschaft (DFG) GR4315/2-2Deutsche Forschungsgemeinschaft (DFG) GR4315/6-1Deutsche Forschungsgemeinschaft (DFG) GRK2338 P08Deutsche Forschungsgemeinschaft (DFG) SFB1328 A21Deutsche Forschungsgemeinschaft (DFG) SFB/TRR152 P04HHS | National Institutes of Health (NIH) DA 054921HHS | National Institutes of Health (NIH) DA 056729HHS | National Institutes of Health (NIH) GM088790NIDA NIH HHS R01 DA054921NIDA NIH HHS R21 DA056729NIGMS NIH HHS R01 GM088790NIH HHS P40 OD010440UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/T015853/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/W01551X/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) UKRI2960
6 · The paper itself

Abstract

Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is permeable to Ca

Indexed as

CalciumCalcium ChannelsLysosomesAllosteric RegulationAnimalsCaenorhabditis elegansHEK293 CellsHumansMutationNADPPermeabilityPhosphatidylinositol PhosphatesTwo-Pore ChannelsCalciumCalcium ChannelsNAADPNADPphosphatidylinositol 3,5-diphosphatePhosphatidylinositol PhosphatesTPCN2 protein, humanTwo-Pore Channels

Identifiers

PMID42567924
PMCPMC13578460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.